Prorenin receptor is needed for podocyte function
نویسندگان
چکیده
منابع مشابه
Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent.
In the present study, we tested the hypothesis that the renoprotective effect of an angiotensin receptor blocker depends on the angiotensin II type 1 (AT(1)) receptor on podocytes. For this purpose, we generated podocyte-specific knockout mice for the AT(1) gene (Agtr1a) and crossed with NEP25, in which selective podocyte injury can be induced by immunotoxin, anti-Tac(Fv)-PE38. Four weeks after...
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This article has no abstract. DOI: 10.18502/jfqhc.6.2.953
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The discovery of the prorenin receptor, now nearly a decade ago, altered our view of the renin-angiotensin system (RAS).1,2 Binding of prorenin, the inactive precursor of renin, to the prorenin receptor results in full catalytic activity of prorenin through a nonproteolytic mechanism that likely involves a conformational change by which the prosegment moves out of the catalytic cleft, which the...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2011
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2011.181